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Fungicides for a strong, sustainable crop
Cut spider mites down to size
A comprehensive guide for vine growers


Get everything you need for a strong, sustainable crop

Certis non-SDHI fruit fungicides let you create IPM programmes that balance efficacy with resistance management.

You’ve conventional and biorational product options for soft and top fruit that enable you to make the most of FRAC guidelines. To support this, several Certis fungicides offer a unique MoA (mode of action).

You’ll tackle key fruit diseases including powdery mildew, Botrytis, apple scab and other surface pathogens.

Most important, you'll be able to 'take more home' - maximum marketable produce - and 'leave less behind' in waste and resistance.

In addition, you've spider mite control across the lifecycle of key species.

And you'll discover conventional and biorational crop solutions for vines.

Naturally, you can rely on the technical expertise of the Certis horticulture team to help you develop effective programmes: we’re committed to take you through to a successful harvest with top-class crops.

Take more home with Certis fruit fungicides

Why Cosine

Cosine is the non-SDHI fungicide for early use on primary powdery mildew in apples and pears – when spores have overwintered in the buds. Effective control helps prevent disease spread and new infections in neighbouring plants.

At the same time, Cosine supports your IPM efforts with low impact on beneficials, and has a convenient 14-day PHI.

Works in two ways

You’ll discover that Cosine provides excellent curative action and lasting protection:
It acts on the plant with both penetrant and translaminar movement. Vapour phase activity ensures best results against secondary powdery mildew, usually from green cluster to July.

It acts on the fungus as a protectant and a curative.

Mode of action

Cosine is invaluable as part of your resistance management strategy. Its active substance, cyflufenamid, gives you extra application options. It’s in the amidoxime chemical group (FRAC U6) and has no known cross-resistance with any chemical classes used against powdery mildew.

You’ll benefit from multi-stage disease control. Cyflufenamid is effective against the formation of haustoria, colonisation of plant tissue, growth of mycelium and the formation of conidiospores.



Trials show that Cosine gives excellent control of powdery mildew at key growth stages.

Easy tank-mixing

Cosine is flexible: you can mix it with Karma and a wide range of fungicides and insecticides in the table. It’s the strongest non-SDHI for top fruit and can be mixed with apple scab-only products such as Delan Pro.

To aid tank-mixing, Cosine is rain-fast after just one hour and stable at pH 4-7 (DT50 -288d pH9).


How Cosine and Karma work with secondary powdery mildew

Secondary powdery mildew on apple leaves, average severity on last 5 leaves. Var. GalaxyGala. 

When to apply

Use from early green cluster to end of new growth, with two applications permitted each season. Curative vapour activity against secondary powdery mildew is best achieved at above 25°C. Your advisor will confirm what is appropriate.

Why Karma for top fruit and vines

Use Karma biorational fungicide for contact control of apple scab (Venturia inaequalis) and Botrytis cinerea in vines (EAMU 2016 1327). 

Karma is ideal for ICM systems. It’s based on an approved food additive (potassium hydrogen carbonate), so there are no residues or MRLs, and just a one-day PHI.

Mode of action

Karma enhances resistance management through multi-stage activity.

It inhibits mycelial growth and causes total collapse of spores by dehydration, pH and specific bicarbonate/carbonate ion effects. What’s more, it helps prevent infection by disrupting the release of hydrolytic enzymes used by fungi to infect plants.

In addition, powerful built-in surfactants (wetters and stickers) promote efficacy, coverage and rain-fastness.



Trials show that Karma is effective against both leaf and fruit scab.

When to apply

For best results apply preventatively at key times. Do not use during the flowering period, on fruit smaller than 10 mm or in the last five weeks before harvest. Applying when leaves are wet can maximise Karma’s efficacy. Your advisor will confirm what is appropriate.

Learn more

We’ve plenty of ways to help:

  • Talk to your advisor or distributor.
  • Read key Cosine or Karma details.
  • Discover five reasons to use Certis non-SDHI fruit fungicides below. 
  • Contact our technical experts on 0845 373 0305 or send us this quick form.


Targeted powdery mildew control for top fruit – curative and long-lasting protectant.

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Biorational eradicant for powdery mildew and scab in apples, powdery mildew and Botrytis in strawberries.

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Why Frupica

Frupica will help prevent Botrytis in your outdoor and protected strawberries. But it does more than that. It’s the only fungicide in FRAC 9 to offer moderate powdery mildew control, giving you an additional resistance management option.

You’ll find using Frupica very flexible. It’s highly IPM compatible with low impact on beneficials and no flower damage. Five-day residual activity makes application manageable close to harvest.

Mode of action

Frupica's active, mepanipyrim, is an anilinopyrimidine that works in contact with the plant. Its MoA reduces mycelium growth and sporulation of conidia.

This is achieved by preventing and disturbing the formation of haustoria and inhibiting:

  • Amino acid (methionine)
  • Production of hydrolytic enzymes (pectinase)
  • Transport of nutrients from plant to fungus


Studies show the efficacy of Frupica in strawberry waiting beds (Rijsbergen 2009)  – so you know you can rely on it.

When to apply

For ever-bearers, apply at or before flowering to prevent diseased petals becoming colonised, and in September/October.  For June bearers and outdoor crops, apply once . Your advisor will confirm what is appropriate.

Why Takumi 

With an EAMU for strawberries (2055/2016), Takumi non-SDHI fungicide offers parallel powdery mildew protection to Cosine in top fruit, yet with an even shorter PHI – just three days. It’s adaptable: you’ll gain preventive or curative activity depending on pathogen pressure and the concentration used.

Takumi is crop-safe, with phytotoxic effects unlikely. The SC formulation is kind to strawberries and Takumi is proven on varieties including Buddy, Elsanta, Sweet Heart, Cambridge Favorite and Malling Centenary.

Takumi is also kind to your beneficials, helping preserve them. Its low impact makes the product highly IPM compatible.

You’ll discover that Takumi is easy to use. It’s rain-fast in one hour, stable at pH 4-7 (DT50 -288d pH9) and provides activity against further foliar diseases.

Mode of action

As with Cosine, Takumi acts on the plant and the fungus to protect against and cure powdery mildew. Penetrant and translaminar with vapour activity at higher temperatures, the multi-stage MoA helps supports resistance management.

The active, cyflufenamid, is in the amidoxime chemical group (FRAC U6) giving greater flexibility. And you can alternate or combine Takumi with products that use different modes of action, such as Karma.




Why Karma for soft fruit

Use Karma biorational fungicide to control powdery mildew and Botrytis in strawberries via its EAMU (0901/2015).

A contact eradicant, Karma is ideal for ICM systems and has just a one-day PHI. It’s based on potassium hydrogen carbonate (an approved food additive), so there are no residues or MRLs to worry about.

Mode of action

Karma enhances resistance management through multi-stage activity.

It inhibits mycelial growth and causes total collapse of spores. What’s more, it helps prevent infection by disrupting the release of hydrolytic enzymes used by fungi to infect plants.

In addition, powerful built-in surfactants promote efficacy, coverage and rain-fastness.



Trials show how effective Karma is against powdery mildew and Botrytis.

When to apply

For best results apply preventatively. Do not use during flowering, on fruit smaller than 10 mm or in the last five weeks before harvest. Applying when leaves are wet can maximise Karma’s efficacy. Your advisor will confirm what is appropriate .

Why Amylo-X 

Amylo-X gives you a further biorational route to prevent Botrytis and powdery mildew. It’s based on a naturally-occurring bacterium, and so can be used on a wide range of permanently protected soft fruit crops, particularly strawberries.

Mode of action

Amylo-X contains Bacillus amyloliquefaciens subsp. plantarum strain D747. This offers a unique MoA that produces anti-fungal compounds, competes with the pathogen for space and prevents spore germination. As a result, it’s ideal for alternation with other Botrytis and powdery mildew products.


In trials, Amylo-X showed strong performance against Botrytis.

When to apply

Use Amylo-X early in the crop life-cycle. You can make six applications per crop with seven days between each. Your advisor will confirm what is appropriate.

Learn more

We’ve plenty of ways to help:

  • Talk to your advisor or distributor. 
  • Read key Frupica, Karma, Takumi, or Amylo-X details. 
  • Discover five reasons to use Certis non-SDHI fruit fungicides below. 
  • Contact our technical experts on 0845 373 0305 or send us this quick form.
Amylo-X WG


Biorational prevention of Botrytis, powdery mildew and Sclerotinia in strawberries (EAMU).

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Frupica SC


True strawberry botryticide with moderate powdery mildew control – preventive.

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Biorational eradicant for powdery mildew and scab in apples, powdery mildew and Botrytis in strawberries.

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Takumi SC


Flexible powdery mildew resistance management EAMU for strawberries – preventive and curative.

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Certis fungicides are more than 'fillers' in your SDHI-based fruit programmes: they're the ideal complement. In what can be a complex set of decisions and treatments, they add valuable benefits you might not expect.

Here’s why to consider Certis fungicides in greater detail. Discover how they'll help you grow great fruit, now and in future seasons.

1. Gain effective control

Depending on your choice of fungicide, you’ll get thorough curative and preventive activity beyond your SHDIs.

Cosine, for example, treats early powdery mildew, and the late secondary form of the disease, to reduce spread and persistence in top fruit. Takumi SC, with an EAMU and crop-safe formulation for strawberries, gives multi-stage disease control. It also has strong vapour activity to optimise systemic penetration.

2. Support resistance management

Being non-SDHIs, our fungicides offer alternative MoAs – that goes without saying. However, you benefit from unique FRAC codes – such as U6 and 9 – together with biorational options, to add variety to your resistance management strategy, short- and long-term.

3. Protect your beneficials

Predatory wasps, mites, midges, ladybirds – whatever species you use – will be able to carry on working.

Our fungicides are low impact and highly IPM compatible to safeguard your investment in beneficial organisms. See our IOBC ratings.


4. Make life easier

Application timings, water volumes, PHIs and crop-safe tank mix options. Everything’s designed to be flexible.

You’ll even find an established fungicide like Frupica SC is more adaptable than you may realise: it’s perfect for early use in 60-day strawberry varieties, with EAMUs for other crops.

And don’t forget: you’ve a selection of increasingly important biorationals to control powdery mildew, scab and Botrytis in top or soft fruit.

5. You're brilliantly backed-up

In conjunction with your  advisor or distributor, you can rely on the technical knowledge of Certis experts to help use our products and get the most from your whole fruit programme.


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Get spider mites back under control with our two IPM-friendly acaricides

Spider mites reduce your marketable crop, threating yield and quality. The effects of untreated infestations can persist beyond the current season with productivity impaired by feeding damage.

Overwintered spider mite eggs are notoriously tricky to spot. If you leave them untreated until there are visible mites and damage at a later growth stage, the canopy is often much denser making control more challenging: mites are often found on the underside of the leaf, so are more difficult to hit.

It’s even harder to distinguish between mite species. Changing weather conditions mean that species are ‘migrating’ to crops where they haven’t previously been seen.

This makes the picture more complicated, as having mixed species at various lifecycle stages and with different multiplication rates in a crop means they are more difficult to tackle and adversely affects the ability of beneficials to manage them alone.

The answer – go early

Use an effective acaricide that targets eggs and larvae – Nissorun®

Follow up if needed at the first signs of mite activity to relieve pressure and give you flexibility for the best chance of control – Kanemite®

Complementary acaricides for season-long control

It’s time to cut spider mites down to size, with Nissorun and Kanemite. They fill gaps in control where other options have been withdrawn, are restricted in use or aren’t IPM-friendly.

Both provide targeted control at key stages. In the long run, you’ll have fewer problems with the most important spider mite species, Two-spotted (Tetranychus urticae) and Fruit Tree Red (Panonychus ulmi), while protecting your macrobiologicals.

Both support IPM, allowing beneficials and natural predators to stay alive and active. They give the variety and novelty you need across IRAC groups to manage resistance, with no cross-resistance to other acaricides including METIs. And you can alternate easily with biopesticides like Majestik for a balanced programme.

Highly cost-effective

Nissorun and Kanemite work on contact activity, so using maximum concentration and achieving optimal spray coverage is essential.

But they deliver more with their ability to tailor dose rate and water volume to the crop growth stage and density. The earlier and smaller the crop, the lower the effective dose and water volume needed to tackle mites. It’s a winning combination.

See how they work

Watch this quick animation: 

See what advisors and growers say







“Very good selectivity with minimal effects on non-target species.”

Following a cold start to the 2021 season, pest development has been slow. However, spider mite populations are set to grow rapidly in orchards favoured by the inevitable increase in temperatures. In orchards where levels of predatory mites are not sufficient to keep pest mites under control, well-timed acaricide applications are necessary. Protected crops are likely to see an exponential increase of spider mite numbers, so thorough and regular pest and beneficials monitoring is very important.

With a general trend of summers getting longer and warmer (Met Office), spider mite crop risk is becoming increasingly important for stone fruit as well as top fruit orchards.

Kanemite is an acaricide with very good selectivity and minimal effects on non-target species, which fits the Agrovista Fruit IPM strategy perfectly. An application gives good knockdown for a range of pest spider mites such as T. urticae, T. cinnabarinus, P. ulmi, etc. Kanemite is effective on all growth stages of the pests, has long residual activity while being safe to the key predators and is a good fit in an IPM approach.

Efficacy is not affected by temperature. It has contact and ingestion activity, so adequate spray coverage is essential to achieve good control. Kanemite should not be tank-mixed with highly alkaline products, as this would affect its efficacy.

Last season’s applications in both stone and top fruit orchards gave good pest control, when they were timed and applied correctly, following thorough crop monitoring, while having minimum impact on beneficials and non-target species.

Alex Radu, Technical Manager, Agrovista Fruit 


"It's all about balance."

A proactive approach with Nissorun and Kanemite maintains the balance between predatory mites and pest mites. This allows for natural suppression through the remainder of the season.

Richard Killian, Fruit Agronomist and Technical Coordinator, Agrii




“If you start low, it’s easier to stay low.”

That’s the approach I recommend to tree fruit and hop growers to reduce spider mite populations throughout the season. Nissorun and Kanemite are valuable additions to the acaricides market. It really helps that they are both IPM-predator-friendly.

Jonathan Blackman, Horticultural Technical Manager, H L Hutchinsons




"The biggest problem - red spider mite."

Charlie Dunn, fruit grower, Chandler & Dunn


Acaricides in depth

Read this article to discover the view of Richard Killian and Jonathan Blackman in detail. First published in Fruit Grower.

Nissorun: the early starter

Resolve initial and overwintered infestations with early application of Nissorun to reduce mite burden later in the season. Its active substance, hexythiazox, conclusively breaks the mite lifecycle by inhibiting the enzyme that catalyses the polymerisation of chitin. Put simply, it’s a mite growth inhibitor.

Use on apples, pears, hops

Single application

Targets Two-spotted and Fruit Tree Red spider mites

Rain-fast and non-systemic

28-day PHI

IRAC Group 10A




Nissorun has excellent activity on egg and larvae stages, but minimal effect on the nymph stage and little to no effect on adult mites, so timing is key.

Maintain maximum concentration and optimum coverage: this can be achieved with a fraction of the full dose depending on time of application. That’s because Nissorun fits with AHDB PACE (Pesticide Adjustment to the Crop Environment) for dose rates tailored to crop growth stages. You’ll also use less water than if you had treated later in the season. Don’t wait, be proactive, get in early.

Kanemite: the fast worker

The sooner you use Kanemite when mites are first active, the more thorough and economical the control.  Always use the maximum concentration whatever the water volume being applied; going early gives flexibility according to crop growth stage and density. Like Nissorun, Kanemite is PACE-compatible. Knockdown and feeding damage stops after just one hour with mortality after around eight hours.

Kanemite controls mites throughout the lifecycle, including eggs, which is especially vital with mixed mite species and lifecycle stages present at the same time. Its Mode of Action (MoA) inhibits electron transport complex III, preventing the use of energy in the mite’s cells, with immediate results. And it provides vital diversity for resistance management as the only acaricide in IRAC Group 20B.

In addition, the need for robust SWD programmes in cherries can often negatively affect beneficials which are key to spider mite control. Kanemite has less impact on these important beneficials while taking care of spider mites.

Use on apples, pears, outdoor cherries

Single application

Targets a range of spider mites including Two-spotted and Fruit Tree Red

Rain-fast in one hour

30-day PHI apples and pears, 21 days cherries

IRAC Group 20B




Kanemite is unaffected by temperature and rain-fast within one hour.

Learn more

We’ve plenty of ways to help:

  • Talk to your advisor or distributor. 
  • Read key Nissorun and Kanemite details. 
  • Contact our technical experts on 0845 373 0305 or send us this quick form.


A suspension concentrate containing 164 g/L acequinocyl for use as an acaricide for control of two-spotted spider mite .

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Suspension concentrate of 250g/L hexythiazox for use as an acaricide control of two-spotted spider mite (Tetranychus urticae).  

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The Vine Growers Guide

Wine GB predicts that in 20 years, UK viticulture could be worth £1bn. A rapid growth in plantings over the past few years has put grapevines on the map as a serious UK fruit crop. Couple this with numerous English Wines consistently performing in terms of quality at European and International levels, its paints an excellent picture for the future of British Wines. 

With the area of grapevines rapidly growing across the country, it is important to take a step back to assess what challenges these crops could face in producing for an ever-increasing demand. Consistent productivity is difficult to acheive with British weather systems being so variable year to year. English sparkling wine yields need to hit a long term average of 8t/ha, while only currently achieving 3t/ha. 

Certis has developed a wide range of conventional and biorational crop solutions to help you develop innovative IPM strategies, vital for sustainable vine production. To read more about the full portfolio, download our Vine Growers Product Guide below. 

Or request a hard copy by filling in this form.

To learn more, talk to your advisor or distributor or contact our techncial hotline on 0845 373 0305.