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Fruit Fungicides

Certis fungicides. Reset your thinking

Certis fungicides enable you to switch your approach to disease control to one that advisors and growers increasingly accept is vital to ensure that crop production stays sustainable:

Lead programmes with non-SDHIs and keep your limited applications of SDHIs in reserve.

With Certis conventional and biorational products, you’ll tackle key fruit diseases including powdery mildew, Botrytis, apple scab and other surface pathogens right now.

But you’ll rebalance your IPM efforts, ensure long-term resistance management and continue to deliver maximum marketable yield.

One of Agrii’s youngest fruit agronomists, Matt Greep advises growers in the West Midlands and the South on top and soft fruit.

Our increasingly unpredictable weather means that the old days of putting on 14-day-PHI chemistry with long persistence and thinking ‘that’s it’ are gone. Plenty of SDHIs are available, of course, but life’s no longer easy, as only a maximum four applications are usually possible per season.

It’s time to avoid reliance on SDHIs and switch disease-control planning to non-SDHIs, including biologicals (or biorationals). Here, the Certis portfolio deals with most needs.

There are three key reasons why changing focus makes sense:

1. Climate change and demand:  the clamour for produce to be on tap for longer has led to growing more produce under protected cover. This forces plants to develop early and continue cropping much later. While polytunnels help plants flourish, they provide ideal conditions for disease. High humidity leads to earlier Botrytis, for example; with more moisture on the crop, there are more sites in which disease can breed. Increased labour costs put higher pressure on fast planting which can sometimes lead to broken plant material at transplanting. This can be an initial infection point for early-season Botrytis.

2. The pressure for more actives: since growers have to maintain plant health against acute diseases for lengthy seasons, they can easily run out of actives. Consequently, growers have to consider all their options. Certis’s Amylo-X and Karma can help lengthen programmes, with zero- or one-day PHIs and the ability to make six or eight applications.

3. Greater flexibility: often, growers don’t appreciate all the advantages of using Certis non-SDHIs. Karma, for instance, can give a week’s protection from early in the season with just one application, making it more than a one-day PHI back-end treatment. As tunnels frequently stay humid overnight and are ventilated in the morning, the crystals in Karma are wet, dry out, then re-wet: this re-activates them repeatedly until spent.

Amylo-X: quick reminder

A preventative biorational that produces anti-fungal compounds to inhibit spore germination. Works by colonising leaves, roots and other plant surfaces. Activated by the plant’s natural defences, enhancing resistance and tolerance. For best control, apply before infection with good coverage.


Tom Deards is farm manager at Pencoyd Court Farm, owned by AJ & CI Snell, which produces high-quality berries on 450 acres of Hereford countryside. He does his own agronomy, with distributor assistance.

“Temperature and humidity can create the perfect storm for powdery mildew in polytunnels. You have to expect the worst and follow best practice, especially when it comes to residue management.

Best practice means starting with cultural control (for example, we remove the soft, young tissue from runners as this attracts powdery mildew as much as the fruit), hygiene and the right balance of fertilisers. Climate control is key: we use temperature and humidity loggers to assess risk during busy periods.

Only then do we consider fungicides – ideally biological (or biorational) – with chemicals as a last resort. As part of our product mix, we use Frupica SC and Takumi SC for powdery mildew and Botrytis. Their short harvest intervals help with our increased use of everbearers.

The Certis portfolio? It gives you all you need to stay on top of disease, both preventively and curatively – with support from SDHIs only when the situation dictates. I’ve no hesitation building programmes around it.”

Frupica SC: quick reminder

A FRAC 9 preventative fungicide for controlling Botrytis and powdery mildew in strawberries. Contact MoA with five-day residual activity. Ideal for season-long use in everbearers, but also valuable early in 60-day varieties.


Chris Cooper has 35 years’ experience as a UK fruit agronomist. He’s a Senior Agronomist in the Hutchinsons Horticultural Team.

The move to protected table-top everbearers means that some diseases have become more prevalent.

Powdery mildew is the major disease threat; growers need to keep the crop as clean as possible before they run into resistance problems and out-of-control products.

Since the maximum number of applications and total dose (SDHIs, strobs and so on) per season are strictly regulated to reduce resistance, we look first at the available chemistry and use friendly biological (biorational) products in-between.

Certis’s mix of MoAs gives a useful range of options. We find that Takumi SC is excellent for prevention, while Amylo-X provides effective powdery mildew control and Karma, with its kind formulation and mycelial eradication properties, is helpful later in the year when pressure is high and disease is established or establishing.

Our advice is simple: rotation prevents resistance, so use robust chemistry at key times – at most two weeks apart – and be sure to slot in your biorationals.

Karma​​​​​​​: quick reminder

A biorational contact eradicant with a one-day PHI, no residues or MRLs. ‘Squeezes the life’ out of powdery mildew and all surface pathogens, so they wither and collapse. Formulated with double adjuvant system; mixes well fungicides for Botrytis control.


Based in Herefordshire, David Taylor is a fruit agronomist at Agrovista and works with top- and soft-fruit growers across most of the UK.

It can be difficult to devise the definitive fungicide programme to best manage diseases such as powdery mildew in a strawberry crop – there are so many cropping situations and every spring & summer is different.

However, it’s clear that multi-acting products are invaluable for treating overwintered disease and preventing new infection. Not only do these products have a greater chance of effect and control than contact fungicides: those with good efficacy against powdery mildew can also be preventative. This gives extended benefits and breathing-space, allowing biofungicides such as Amylo-X and Karma to be introduced into a fungicide programme.

Takumi is such a product. Use it on everbearers at harvest and you’re very likely to get on top of powdery mildew, provided you can manage a three-day PHI.

For those growing June bearers, Takumi SC is also useful during flowering, at the highest point of disease pressure and up to three days before harvest. Its vapour activity and the opportunity to use lower water rates are attractive.

Takumi SC: quick reminder

The non-SDHI of choice in crops using lower spray water volumes against powdery mildew. Excellent curative results with lasting protection and resistance management. Combined multi-stage and strong vapour activity. Crop-safe formulation: highly IPM-compatible with low impact on beneficials.


Simon Warren is a ‘career’ fruit agronomist at Agrovista. He provides a wealth of experience in soft fruit and covers the south of England from his Kent base.

SDHIs do have limitations – we accept that.

Our method is to build programmes around a seven-day regime, with more persistent chemicals early on. We factor in three SDHI applications (four if applying 11+ sprays per season to meet FRAC guidelines).

However, we hold SDHIs back for when disease pressure is high and picking intervals are tight to benefit from their eradicant properties.

Certis’s biorational Karma is also valuable in high-pressure situations: we find that we gain control faster and more effectively than with the commodity substance and need to spray less. This results in reduced leaf damage to the crop.

Karma’s one-day PHI gives flexibility at picking and clears up powdery mildew nicely. We tank-mix or follow up with Frupica SC or Takumi SC for added protectant and/or eradicant activity.

So, yes, we recommend using non-SDHIs between sprays.


“Cosine gives really good control through its vapour activity.”

Alex Radu, Technical Manager, Agrovista Fruit

"Primary powdery mildew is a problem as soon as temperatures pick up, because sporulation accelerates at the same time as growth of new plant tissue develops more rapidly. New tissue of the extension growth is susceptible to infections, while older leaves with thicker waxy cuticle are resistant.

Cosine has a curative activity on both primary and secondary mildew - it reduces sporulation and also protects new tissue. This, in turn, helps reduce the threat of secondary powdery mildew.

As they estimate infection risk based on available weather data, such as temperature and moisture levels that drive sporulation, powdery mildew forecasting models are valuable tools to make best use of products like Cosine. When temperatures rise to 22-25’C, Cosine gives really good control through its vapour activity.

Growers have a good choice of SDHIs, but a limited number of applications in a growing season – four at most – in order to preserve their efficacy. So the use of non-SDHIs has to form an important part of any fungicide plan.”


“To eradicate mildew, the best tool may be a non-SDHI.”

Richard Killian, Fruit Agronomist and Technical Coordinator, Agrii

"Rotation of actives and FRAC guidelines are the cornerstones of an approach to avoid localised and widespread resistance – they’re vital to maintain the strength of our total armour against mildew.

SDHIs have become mainstays in most programmes, but over-use will probably start to weaken some useful new actives and may already be doing so. Where growers need to eradicate mildew, the best tool for the job may be a non-SDHI.”


Why Cosine

Cosine is the non-SDHI fungicide for early use on primary powdery mildew in apples and pears – when spores have overwintered in the buds. Effective control helps prevent disease spread and new infections in neighbouring plants.

At the same time, Cosine supports your IPM efforts with low impact on beneficials, and has a convenient 14-day PHI.

Works in two ways

You’ll discover that Cosine provides excellent curative action and lasting protection:
It acts on the plant with both penetrant and translaminar movement. Vapour phase activity ensures best results against secondary powdery mildew, usually from green cluster to July.

It acts on the fungus as a protectant and a curative.

Mode of action

Cosine is invaluable as part of your resistance management strategy. Its active substance, cyflufenamid, gives you extra application options. It’s in the amidoxime chemical group (FRAC U6) and has no known cross-resistance with any chemical classes used against powdery mildew.

You’ll benefit from multi-stage disease control. Cyflufenamid is effective against the formation of haustoria, colonisation of plant tissue, growth of mycelium and the formation of conidiospores.



Trials show that Cosine gives excellent control of powdery mildew at key growth stages.

Easy tank-mixing

Cosine is flexible: you can mix it with Karma and a wide range of fungicides and insecticides in the table. It’s the strongest non-SDHI for top fruit and can be mixed with apple scab-only products such as Delan Pro.

To aid tank-mixing, Cosine is rain-fast after just one hour and stable at pH 4-7 (DT50 -288d pH9).


How Cosine and Karma work with secondary powdery mildew

Secondary powdery mildew on apple leaves, average severity on last 5 leaves. Var. GalaxyGala. 

When to apply

Use from early green cluster to end of new growth, with two applications permitted each season. Curative vapour activity against secondary powdery mildew is best achieved at above 25°C. Your advisor will confirm what is appropriate.

Why Karma for top fruit and vines

Use Karma biorational fungicide for contact control of apple scab (Venturia inaequalis) and Botrytis cinerea in vines (EAMU 2016 1327). 

Karma is ideal for ICM systems. It’s based on an approved food additive (potassium hydrogen carbonate), so there are no residues or MRLs, and just a one-day PHI.

Mode of action

Karma enhances resistance management through multi-stage activity.

It inhibits mycelial growth and causes total collapse of spores by dehydration, pH and specific bicarbonate/carbonate ion effects. What’s more, it helps prevent infection by disrupting the release of hydrolytic enzymes used by fungi to infect plants.

In addition, powerful built-in surfactants (wetters and stickers) promote efficacy, coverage and rain-fastness.



Trials show that Karma is effective against both leaf and fruit scab.

When to apply

For best results apply preventatively at key times. Do not use during the flowering period, on fruit smaller than 10 mm or in the last five weeks before harvest. Applying when leaves are wet can maximise Karma’s efficacy. Your advisor will confirm what is appropriate.

Learn more

We’ve plenty of ways to help:

  • Talk to your advisor or distributor.
  • Read key Cosine or Karma details.
  • Discover five reasons to use Certis non-SDHI fruit fungicides below. 
  • Contact our technical experts on 0845 373 0305 or send us this quick form.


Targeted powdery mildew control for top fruit – curative and long-lasting protectant.

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Biorational eradicant for powdery mildew and scab in apples, powdery mildew and Botrytis in strawberries.

See more…

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Why Frupica

Frupica will help prevent Botrytis in your outdoor and protected strawberries. But it does more than that. It’s the only fungicide in FRAC 9 to offer moderate powdery mildew control, giving you an additional resistance management option.

You’ll find using Frupica very flexible. It’s highly IPM compatible with low impact on beneficials and no flower damage. Five-day residual activity makes application manageable close to harvest.

Mode of action

Frupica's active, mepanipyrim, is an anilinopyrimidine that works in contact with the plant. Its MoA reduces mycelium growth and sporulation of conidia.

This is achieved by preventing and disturbing the formation of haustoria and inhibiting:

  • Amino acid (methionine)
  • Production of hydrolytic enzymes (pectinase)
  • Transport of nutrients from plant to fungus


Studies show the efficacy of Frupica in strawberry waiting beds (Rijsbergen 2009)  – so you know you can rely on it.

When to apply

For ever-bearers, apply at or before flowering to prevent diseased petals becoming colonised, and in September/October.  For June bearers and outdoor crops, apply once . Your advisor will confirm what is appropriate.

Why Takumi 

With an EAMU for strawberries (2055/2016), Takumi non-SDHI fungicide offers parallel powdery mildew protection to Cosine in top fruit, yet with an even shorter PHI – just three days. It’s adaptable: you’ll gain preventive or curative activity depending on pathogen pressure and the concentration used.

Takumi is crop-safe, with phytotoxic effects unlikely. The SC formulation is kind to strawberries and Takumi is proven on varieties including Buddy, Elsanta, Sweet Heart, Cambridge Favorite and Malling Centenary.

Takumi is also kind to your beneficials, helping preserve them. Its low impact makes the product highly IPM compatible.

You’ll discover that Takumi is easy to use. It’s rain-fast in one hour, stable at pH 4-7 (DT50 -288d pH9) and provides activity against further foliar diseases.

Mode of action

As with Cosine, Takumi acts on the plant and the fungus to protect against and cure powdery mildew. Penetrant and translaminar with vapour activity at higher temperatures, the multi-stage MoA helps supports resistance management.

The active, cyflufenamid, is in the amidoxime chemical group (FRAC U6) giving greater flexibility. And you can alternate or combine Takumi with products that use different modes of action, such as Karma.




Why Karma for soft fruit

Use Karma biorational fungicide to control powdery mildew and Botrytis in strawberries via its EAMU (0901/2015).

A contact eradicant, Karma is ideal for ICM systems and has just a one-day PHI. It’s based on potassium hydrogen carbonate (an approved food additive), so there are no residues or MRLs to worry about.

Mode of action

Karma enhances resistance management through multi-stage activity.

It inhibits mycelial growth and causes total collapse of spores. What’s more, it helps prevent infection by disrupting the release of hydrolytic enzymes used by fungi to infect plants.

In addition, powerful built-in surfactants promote efficacy, coverage and rain-fastness.



Trials show how effective Karma is against powdery mildew and Botrytis.

When to apply

For best results apply preventatively. Do not use during flowering, on fruit smaller than 10 mm or in the last five weeks before harvest. Applying when leaves are wet can maximise Karma’s efficacy. Your advisor will confirm what is appropriate .

Why Amylo-X 

Amylo-X gives you a further biorational route to prevent Botrytis and powdery mildew. It’s based on a naturally-occurring bacterium, and so can be used on a wide range of permanently protected soft fruit crops, particularly strawberries.

Mode of action

Amylo-X contains Bacillus amyloliquefaciens subsp. plantarum strain D747. This offers a unique MoA that produces anti-fungal compounds, competes with the pathogen for space and prevents spore germination. As a result, it’s ideal for alternation with other Botrytis and powdery mildew products.


In trials, Amylo-X showed strong performance against Botrytis.

When to apply

Use Amylo-X early in the crop life-cycle. You can make six applications per crop with seven days between each. Your advisor will confirm what is appropriate.

Learn more

We’ve plenty of ways to help:

  • Talk to your advisor or distributor. 
  • Read key Frupica, Karma, Takumi, or Amylo-X details. 
  • Discover five reasons to use Certis non-SDHI fruit fungicides below. 
  • Contact our technical experts on 0845 373 0305 or send us this quick form.
Amylo-X WG


Biorational prevention of Botrytis, powdery mildew and Sclerotinia in strawberries (EAMU).

See more…
Frupica SC


True strawberry botryticide with moderate powdery mildew control – preventive.

See more…


Biorational eradicant for powdery mildew and scab in apples, powdery mildew and Botrytis in strawberries.

See more…
Takumi SC


Flexible powdery mildew resistance management EAMU for strawberries – preventive and curative.

See more…

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In what can be a complex set of decisions and treatments, Certis non-SDHIs add valuable benefits to your disease control programme.

Here are five further reasons to consider Certis fungicides. Discover how they'll help you grow great fruit, now and in future seasons.

1. Gain effective control

Depending on your choice of fungicide, you’ll get thorough curative and preventive activity beyond your SHDIs.

Cosine, for example, treats early powdery mildew, and the late secondary form of the disease, to reduce spread and persistence in top fruit. Takumi SC, with an EAMU and crop-safe formulation for strawberries, gives multi-stage disease control. It also has strong vapour activity to optimise systemic penetration.

2. Support resistance management

Being non-SDHIs, our fungicides offer alternative MoAs – that goes without saying. However, you benefit from unique FRAC codes – such as U6 and 9 – together with biorational options, to add variety to your resistance management strategy, short- and long-term.

3. Protect your beneficials

Predatory wasps, mites, midges, ladybirds – whatever species you use – will be able to carry on working.

Our fungicides are low impact and highly IPM compatible to safeguard your investment in beneficial organisms. See our IOBC ratings.


4. Make life easier

Application timings, water volumes, PHIs and crop-safe tank mix options. Everything’s designed to be flexible.

You’ll even find an established fungicide like Frupica SC is more adaptable than you may realise: it’s perfect for early use in 60-day strawberry varieties, with EAMUs for other crops.

And don’t forget: you’ve a selection of increasingly important biorationals to control powdery mildew, scab and Botrytis in top or soft fruit.

5. You're brilliantly backed-up

In conjunction with your  advisor or distributor, you can rely on the technical knowledge of Certis experts to help use our products and get the most from your whole fruit programme.


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